1. Quick detail 

Product name: Tibolone (Steroids)
Synonyms: LIVIELLA; LIVIAL
CAS: 5630-53-5
EINECS: 227-069-1
MF: C21H28O2
MW: 312.45
Character: White powder
MP: 169.
Melting point: 169 °C
Storage temp. 2-8°C
Product Categories: Active Pharmaceutical Ingredients;
Hormone;Acetylenes;Biochemistry;Functionalized Acetylenes;Hydroxyketosteroids;Steroids;
Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone
Usage: A synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome .

2. Tibolone Cycle for your reference

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3. Tibolone information

Tibolone is a synthetic estrogen steroid hormone that acts as an agonist for multiple I-type steroid receptors and therefore has weak estrogen and progestogen activity as well as some androgenic properties. The parent compound is not active but is metabolized to the active form via tissue-specific metabolism of the sulfatase, which provides estrogenic action without the need for simultaneous use of progesterone. Tibolone also appears to have reduced estrogenic activity in breast tissue. Has been proven effective against menopausal symptoms and the prevention of postmenopausal osteoporosis; it is approved in several European countries, but not the United States. Tibolone can be 1.25 and 2.5 mg tablets for Livial. Side effects include vaginal bleeding, abdominal pain, weight gain, bloating, breast tenderness, genital itching and vaginitis.

4. Tibolone effect

1. Tibolone is a synthetic steroid hormone from the Mexican

2. The metabolites of tibolone have estrogen, androgen and progesterone effects

3. Tibolone has estrogen-like effects (prevention of rinsing), bones (preventing bone loss) and vaginal tissue (preventing dryness and soreness) in the brain,

Tibolone also has a progestogen-like effect in the uterus to prevent endometrial thickening and subsequent bleeding. Women who do not have hysterectomy do not need to take progesterone if they take tibolone.

4. Tibolone has activities like testosterone, which seem to play a role in enhancing women's mood and sexuality, although the response is variable.

5. Tibolone Application

Tibolone/Livial is used mainly for treatment of endometriosis, as well as hormone replacement therapy in post-menopausal women. Tibolone is a synthetic steroid hormone drug, which is fairly non-selective in its binding profile, acting as an agonist mainly at estrogen receptors, with a preference for ER alpha. Tibolone has similar or greater efficacy compared to older hormone replacement drugs, but shares a similar side effect profile. It has also been investigated as a possible treatment for female sexual dysfunction.

Tibolone is a synthetic hormone-type drug which is used mainly for hormone replacement therapy in post-menopausal women. It is a synthetic steroid that has the same activity as the female sex hormones estrogen and progesterone and the androgen testosterone. Tibolone helps restore hormonal balance in the body.

When estrogen levels are low tissues can slowly degenerate, as is experienced during menopause. In addition, low levels of estrogen can cause distressing symptoms such as hot flushes, night sweats, mood swings, reduced sex drive and vaginal dryness. Tibolone is broken down into three compounds which act in a similar way to the natural estrogen and progesterone found in the body. It restores plasma endorphin level in post-menopausal women and acts centrally to affect the thermo-regulatory system.

6. Tibolone Specification

7. Tibolone dose

Take 2.5 mg tablets daily. You can take tibolone at any time in the most easy to remember day, but try taking your dose at the same time every day. You can take tablets before or after meals. You may find that there is little water to swallow the tablet.

If you forget to take the dose, please remember as soon as possible, unless late for more than 12 hours. If you are late for more than 12 hours, please leave a forgotten dose and take your next tablet at the usual time. Do not take two tablets together to compensate for the dose.

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