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Product name : Sildenafil Citrate
Other name: Sildenafil; Viagra
CAS register number: 171599-83-0
Molecular formula: C28H38N6O11S
Molecular weight : 666.7
Melting point: 187-189°C
Usage: Sildenafil citrate, sold as Viagra, Revatio and under various other trade names, is a drug used to treat erectile dysfunction and pulmonary arterial hypertension (PAH). It was originally discovered by Pfizer scientists Andrew Bell, David Brown, and Nicholas Terrett. It acts by inhibiting cGMP-specific phosphodiesterase type 5 (PDE5), an enzyme that promotes degradation of cGMP, which regulates blood flow in the penis. Since becoming available in 1998, sildenafil has been the prime treatment for erectile dysfunction; its primary competitors on the market are tadalafil (Cialis) and vardenafil (Levitra) .
Sldenafil citrate (Viagra) description
Sildenafil citrate is the raw material of Viagra, viagra treats erectile dys function and works by relaxing muscles and increases blood flow to particular areas of the body (in this case, the penis, specifically). Its effects last up to four hours. The most common side effects of Viagra are headache, facial flushing, and upset stomach. Rarely, blurred vision, or sensitivity to light may briefly occur.
As well as treating impotence, Sildenafil Citrate can also be effective in treating Pulmonary Arterial Hypertension (PAH). Similarly to how it acts to relax muscles of the penis, it relaxes arterial walls; therefore, reducing resistance and pressure in the arteries.
Sildenafil Citrate is solely active in relaxing muscles and increasing blood flow to the heart, lungs and penis due to PDE-5, yet vasodilation is not increased in other parts of the body.
Sldenafil citrate (Viagra) Application
In 16 separate 4-24 week trials of men (over 18 years old) who suffered from impotence for longer than 6 months, dosages between 10-200 mgs were administered. Significant improvements in erectile function, including frequency of penetration as well as erection duration post penetration, were reported with Sildenfil treatment compared to the placebo group.
Erections were improved in 72% of the Viagra group verses 18% of the placebo group. In all cases effects were dependant upon dosage and improvement was the greatest when dosage exceeded 100 mgs. Responses were decreased by 40-60% in patients suffering from diabetes and prostatectomy, respectively. Withdrawal rates were less than 5% related to negative side effects and limited response rates .
Sldenafil citrate (Viagra) Specification
| Product name | Sildenafil Citrate | |
| Appearance | White crystalline powder | |
| Loss on drying | ≤1.0% | 0.38% |
| Acidity | 3.0-5.0 | 4.2 |
| Residue on ignition | ≤0.1% | 0.05% |
| Heavy metals | ≤20ppm | Complies |
| Relevant impurity | ≤0.5% | 0.04% |
| Methanol | ≤0.3% | 0.024% |
| Methylene dichloride | ≤0.06% | 0.016% |
| N,N-Dimethyl formamide | ≤0.088% | Not detected |
| Assay(on dried basis) | ≥98% | 98.7% |
Cialis Vs. Levitra Vs. Viagra
Cialis, Levitra, and Viagra are oral medications used to treat erectile dysfunction (ED). You may also know them by their generic names, tadalafil (Cialis), vardenafil (Levitra), and sildenafil (Viagra).
About 30 million men occasionally have a problem with getting or keeping an erection, according to the Urology Care Foundation. When ED becomes a problem, many men turn to oral ED medications. These drugs often help. Cialis, Levitra, and Viagra each work in similar ways. But there are also some differences, such as when you take them, how long they work, and what their side effects are.
Cialis, Levitra, and Viagra are all in a class of drugs called PDE-5 inhibitors. These drugs work by blocking an enzyme called phosphodiesterase type 5. They also boost a chemical in your body called nitric oxide. This action encourages the muscles in your penis to relax. Relaxed muscles allow blood to flow freely so that when you’re aroused, you can get an erection. It also helps you maintain the erection long enough to have sex.
Levitra and Viagra stay in your bloodstream for about four to six hours. Cialis remains in your bloodstream for 17 to 18 hours or longer. The length of time a drug stays in your system may be important if you’re taking other medications.
Here are more basics on each of these drugs
| Brand name | Cialis | Levitra | Viagra |
| What is the generic drug? | tadalafil | vardenafil | sildenafil |
| Is a generic version available? | no | no | no |
| What does it treat? | erectile dysfunction | erectile dysfunction | erectile dysfunction |
| What form does it come in? | oral tablet | oral tablet | oral tablet |
| What strengths does it come in? | 2.5 mg, 5 mg, 10 mg, 20 mg | 2.5 mg, 5 mg, 10 mg, 20 mg | 25 mg, 50 mg, 100 mg |
| When do I take it? | 30-60 mins before sex or once daily | 30-60 mins before sex | 30-60 mins before sex |
| How long does it work? | up to 36 hours | up to 8 hours | 4-5 hours |
| Should I take it with food? | take it with or without food | take it with or without food | take it with or without food |
| How do I store it? | store at room temperature close to 77°F (25°C) | store at room temperature close to 77°F (25°C) | store at room temperature close to 77°F (25°C) |
| Does this drug have potential for misuse? | yes* | yes* | yes* |
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