Product name: Dapoxetine HCL
Appearance: White powder, odorless, sweet, soluble in water, alcohol. Can be made into tablets, beverages, wine, capsules and other dosage forms
CAS No.: 119356-77-3 / 129938-20-1
Molecular Formula: C21H23NO HCL

Molecular Weight: 341.88

Appearance: White crystal powder with sweet taste and no odor, hygroscopic and soluble in water. It has a stable chemical property with the melting point at 175~177℃.
Usage: Dapoxetine (dapoxetine) as a new fast SSRI, a short half life, a selective 5 - HT reuptake inhibitor (SSRI), for the treatment of premature ejaculation and erectile dysfunction. Dapoxetine is a selective 5 - HT reuptake inhibitor (SSRI), such drugs widely used to treat depression and related affective disorders

Dapoxetine HCL Specification

Dapoxetine HCL descripition 

Dapoxetine is the first compound developed specially for the treatment ofpremature ejaculation (PE) in men 18-64 years old. Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin's action at the post synaptic cleft, and as a consequence promoting ejaculatory delay.

Premature ejaculation (PE) is the most common male sexual dysfunction. Dapoxetine hydrochloride,marketed as Priligy and Westoxetin, is a class of PE treatment drugs known as selective serotonin reuptake inhibitors (SSRI) , was the first drug originally approved for the on-demand treatment of men 18–64 years old with PE.

Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin's action at the post synaptic cleft, and as a result promoting ejaculatory delay. Dapoxetine was initially developed as an antidepressant. However, unlike other SSRIs, dapoxetine is absorbed and eliminated rapidly in the body. Its fast acting property makes it suitable for the treatment of PE but not as an antidepressant.
Used for the treatment of premature ejaculation and erectile dysfunction. Over 98% of men taking this drug will naturally gain a improved erection quality with prolonged time and more frequencies.

Treatment of PE 

Premature ejaculation (PE) is a common problem worldwide and has significant impact not only on the sufferer but on the partner in terms of self-esteem, interpersonal distress and sexual satisfaction. Tricyclic antidepressants and clomipramine are the most widely used drugs for the treatment of premature ejaculation .

Randomized, double blind, placebo-controlled trials have confirmed the efficacy of dapoxetine for the treatment of PE. Different dosage has different impacts on different type of PE. Dapoxetine 60 mg significantly improves the mean intravaginal ejaculation latency time (IELT) compared to that of dapoxetine 30 mg in men with lifelong PE, but there is no difference in men with acquired PE. Dapoxetine, giving 1–3 hours before sexual episode, prolongs IELT, increases the sense of control and sexual satisfaction in men of 18 to 64 years of age with PE. Since PE is associated with personal distress, interrelationship difficulty, dapoxetine provides help for men with PE to overcome this condition. Because lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used as off label drugs to treat PE. Waldinger's meta analysis shows that the use of these conventional antidepressants increasing IELT from two to ninefold above base line in comparison of three to eightfold when dapoxetine is used.

However, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence increased of adverse effects such as decreasing sexual libido and causing erectile dysfunction. Dapoxetine, on the other hand, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours. This favorable pharmacokinetics minimizes the risk of the drug's accumulation in the body, and therefore reducing side effects.

Dapoxetine Hydrochloride Function

1. Dapoxetine is the only approved medication to treat premature ejaculation.

2. It is absorbed by stomach, and can be effected after 30-60mins, could be last for 72 hours without side-effect, can't be detected, accompanying light headache, sick, but can disappear soon.

3. Advantages: less dose,rapid onset, long half life and safety.

Premature ejaculation is a common problem among men, and research suggests that a third of men suffer from this sexual dysfunction at one time or another. It is more common than erectile dysfunction (the inability to maintain an erection). For some men, premature ejaculation is frequent enough to cripple their sex lives. Dapoxetine hydrochloride is the first pharmaceutical approach for treating premature ejaculation that has shown some degree of success.

Less dose ,rapid onset, long half life and safety.
Premature ejaculation is a common problem among men, and research suggests that a third of men suffer from this sexual dysfunction at one time or another. It is more common than erectile dysfunction (the inability to maintain an erection). For some men, premature ejaculation is frequent enough to cripple their sex lives.

How to use Dapoxetine ?

The best time to consume is to take the drug 60 to 120 minutes before the planned sex. Dapoxetine is capable to delay the ejaculate after penetration hence providing more time to the couple to enjoy and have fun. However, in most men the effect loses after 3 to 5 hours however some have claimed to retain the effect for as long as 8 hours. Research has revealed that Dapoxetine, in its oral form has found to give better result in more than 75% of men. However, it may react in different person with different intensity, but has found to provide satisfactory results in most of the cases

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